Ceramide accumulation induces mitophagy and impairs β-oxidation in PINK1 deficiency
Ceramide accumulation induces mitophagy and impairs β-oxidation in PINK1 deficiency
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Energy production via the mitochondrial electron transport chain (ETC) and mitophagy are two important processes affected in Parkinson’s disease (PD). Interestingly, PINK1, mutations of which cause early-onset PD, plays a key role in both processes, suggesting that these two mechanisms are connected. However, the converging link of both pathways cu...
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Full title
Ceramide accumulation induces mitophagy and impairs β-oxidation in PINK1 deficiency
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8639384
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8639384
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2025347118
