Loss of CDX2 in colorectal cancer is associated with histopathologic subtypes and microsatellite ins...
Loss of CDX2 in colorectal cancer is associated with histopathologic subtypes and microsatellite instability but is prognostically inferior to hematoxylin–eosin-based morphologic parameters from the WHO classification
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Author / Creator
Konukiewitz, Björn , Schmitt, Maxime , Silva, Miguel , Pohl, Junika , Lang, Corinna , Steiger, Katja , Halfter, Kathrin , Engel, Jutta , Schlitter, Anna Melissa , Boxberg, Melanie , Pfarr, Nicole , Wilhelm, Dirk , Foersch, Sebastian , Tschurtschenthaler, Markus , Weichert, Wilko and Jesinghaus, Moritz
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Background
Immunohistochemical loss of CDX2 has been proposed as a biomarker of dismal survival in colorectal carcinoma (CRC), especially in UICC Stage II/III. However, it remains unclear, how CDX2 expression is related to central hematoxylin–eosin (HE)-based morphologic parameters defined by 2019 WHO classification and how its prognostic releva...
Alternative Titles
Full title
Loss of CDX2 in colorectal cancer is associated with histopathologic subtypes and microsatellite instability but is prognostically inferior to hematoxylin–eosin-based morphologic parameters from the WHO classification
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8651779
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8651779
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/s41416-021-01553-0
