Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and...
Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles
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Author / Creator
Díaz-Sáez, Francisco , Blanco-Sinfreu, Carla , Archilla-Ortega, Adrià , Sebastian, David , Romero, Montserrat , Hernández-Alvarez, Maria Isabel , Mora, Sílvia , Testar, Xavier , Ricart, Wifredo , Fernández-Real, José Manuel , Moreno-Navarrete, José María , Aragonés, Julián , Camps, Marta , Zorzano, Antonio and Gumà, Anna
Publisher
Switzerland: MDPI AG
Journal title
Language
English
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Publisher
Switzerland: MDPI AG
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Scope and Contents
Contents
The adipokine Neuregulin 4 (Nrg4) protects against obesity-induced insulin resistance. Here, we analyze how the downregulation of Nrg4 influences insulin action and the underlying mechanisms in adipocytes. Validated shRNA lentiviral vectors were used to generate scramble (Scr) and Nrg4 knockdown (KD) 3T3-L1 adipocytes. Adipogenesis was unaffected i...
Alternative Titles
Full title
Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles
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Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8657571
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8657571
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ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms222312960
