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Structure and function of retroviral integrase

Structure and function of retroviral integrase

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8671357

Structure and function of retroviral integrase

About this item

Full title

Structure and function of retroviral integrase

Publisher

London: Nature Publishing Group UK

Journal title

Nature reviews. Microbiology, 2022-01, Vol.20 (1), p.20-34

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the viral enzyme responsible for the catalytic steps involved in this process, and integrase strand transfer inhibitors are widely used to treat people living with H...

Alternative Titles

Full title

Structure and function of retroviral integrase

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8671357

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8671357

Other Identifiers

ISSN

1740-1526

E-ISSN

1740-1534

DOI

10.1038/s41579-021-00586-9

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