Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation
Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation
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Author / Creator
Li, Rongqing , Li, Xueqin , Zhao, Jie , Meng, Fandong , Yao, Chen , Bao, Ensi , Sun, Na , Chen, Xin , Cheng, Wanpeng , Hua, Hui , Li, Xiangyang , Wang, Bo , Wang, Hui , Pan, Xiucheng , You, Hongjuan , Yang, Jing and Ikezoe, Takayuki
Publisher
Australia: Ivyspring International Publisher Pty Ltd
Journal title
Language
English
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Publisher
Australia: Ivyspring International Publisher Pty Ltd
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Contents
We found that a subset of signal transducer and activator of transcription 3 (STAT3) translocated into mitochondria in phagocytes, including macrophages isolated from individuals with sepsis. However, the role of mitochondrial STAT3 in macrophages remains unclear.
To investigate the function of mitochondrial STAT3
, we generated inducible mit...
Alternative Titles
Full title
Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8692896
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8692896
Other Identifiers
ISSN
1838-7640
E-ISSN
1838-7640
DOI
10.7150/thno.63751
