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Aged skeletal stem cells generate an inflammatory degenerative niche

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Aged skeletal stem cells generate an inflammatory degenerative niche

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8721524

Aged skeletal stem cells generate an inflammatory degenerative niche

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London: Nature Publishing Group UK

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Loss of skeletal integrity during ageing and disease is associated with an imbalance in the opposing actions of osteoblasts and osteoclasts
1
. Here we show that intrinsic ageing of skeletal stem cells (SSCs)
2
in mice alters signalling in the bone marrow niche and skews the differentiation of bone and blood lineages, leading to fragile...

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Full title

Aged skeletal stem cells generate an inflammatory degenerative niche

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8721524

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8721524

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ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-021-03795-7

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