Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney dise...
Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease
About this item
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Author / Creator
Yin, Fan , Zheng, Pei-qing , Zhao, Liu-qi , Wang, Yan-zhe , Miao, Nai-jun , Zhou, Zhuan-li , Cheng, Qian , Chen, Pan-pan , Xie, Hong-yan , Li, Jing-yao , Ni, Jia-yun , Zhou, Li , Zhang, Wei , Wang, Xiao-xia , Liu, Jun and Lu, Li-min
Publisher
Singapore: Springer Singapore
Journal title
Language
English
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Publication information
Publisher
Singapore: Springer Singapore
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Scope and Contents
Contents
Ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI) in clinic. The activation of NLRP3 inflammasome is associated with inflammation and renal injury in I/R-induced AKI. In the current study we explored the molecular and cellular mechanisms for NLRP3 inflammasome activation following renal I/R. Mice were subjected to I/R...
Alternative Titles
Full title
Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8724289
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8724289
Other Identifiers
ISSN
1671-4083
E-ISSN
1745-7254
DOI
10.1038/s41401-021-00619-2
