Discovery of novel antagonists targeting the DNA binding domain of androgen receptor by integrated d...
Discovery of novel antagonists targeting the DNA binding domain of androgen receptor by integrated docking-based virtual screening and bioassays
About this item
Full title
Author / Creator
Pang, Jin-ping , Shen, Chao , Zhou, Wen-fang , Wang, Yun-xia , Shan, Lu-hu , Chai, Xin , Shao, Ying , Hu, Xue-ping , Zhu, Feng , Zhu, Dan-yan , Xiao, Li , Xu, Lei , Xu, Xiao-hong , Li, Dan and Hou, Ting-jun
Publisher
Singapore: Springer Singapore
Journal title
Language
English
Formats
Publication information
Publisher
Singapore: Springer Singapore
Subjects
More information
Scope and Contents
Contents
Androgen receptor (AR), a ligand-activated transcription factor, is a master regulator in the development and progress of prostate cancer (PCa). A major challenge for the clinically used AR antagonists is the rapid emergence of resistance induced by the mutations at AR ligand binding domain (LBD), and therefore the discovery of novel anti-AR therap...
Alternative Titles
Full title
Discovery of novel antagonists targeting the DNA binding domain of androgen receptor by integrated docking-based virtual screening and bioassays
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8724294
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8724294
Other Identifiers
ISSN
1671-4083
E-ISSN
1745-7254
DOI
10.1038/s41401-021-00632-5
