HIV-1 hypermethylated guanosine cap licenses specialized translation unaffected by mTOR
HIV-1 hypermethylated guanosine cap licenses specialized translation unaffected by mTOR
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Appended to the 5′ end of nascent RNA polymerase II transcripts is 7-methyl guanosine (m⁷G-cap) that engages nuclear cap-binding complex (CBC) to facilitate messenger RNA (mRNA) maturation. Mature mRNAs exchange CBC for eIF4E, the rate-limiting translation factor that is controlled through mTOR. Experiments in immune cells have now documented HIV-1...
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Full title
HIV-1 hypermethylated guanosine cap licenses specialized translation unaffected by mTOR
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8740576
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8740576
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2105153118
