SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes
SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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SF3B1 is the most frequently mutated RNA splicing factor in cancer, including in ∼25% of myelodysplastic syndromes (MDS) patients. SF3B1-mutated MDS, which is strongly associated with ringed sideroblast morphology, is characterized by ineffective erythropoiesis, leading to severe, often fatal anemia. However, functional evidence linking SF3B1 mutat...
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Full title
SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8740767
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8740767
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2111703119
