NR1D1 regulation by Ran GTPase via miR4472 identifies an essential vulnerability linked to aneuploid...
NR1D1 regulation by Ran GTPase via miR4472 identifies an essential vulnerability linked to aneuploidy in ovarian cancer
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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While aneuploidy is a main enabling characteristic of cancers, it also creates specific vulnerabilities. Here we demonstrate that Ran inhibition targets epithelial ovarian cancer (EOC) survival through its characteristic aneuploidy. We show that induction of aneuploidy in rare diploid EOC cell lines or normal cells renders them highly dependent on...
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NR1D1 regulation by Ran GTPase via miR4472 identifies an essential vulnerability linked to aneuploidy in ovarian cancer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8755527
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8755527
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-021-02082-z
