Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis ind...
Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors
About this item
Full title
Author / Creator
Publisher
England: Taylor & Francis
Journal title
Language
English
Formats
Publication information
Publisher
England: Taylor & Francis
Subjects
More information
Scope and Contents
Contents
Based on quinazoline, quinoxaline, and nitrobenzene scaffolds and on pharmacophoric features of VEGFR-2 inhibitors, 17 novel compounds were designed and synthesised. VEGFR-2 IC
50
values ranged from 60.00 to 123.85 nM for the new derivatives compared to 54.00 nM for sorafenib. Compounds 15
a
, 15
b
, and 15
d
showed IC
50...
Alternative Titles
Full title
Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8757611
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8757611
Other Identifiers
ISSN
1475-6366,1475-6374
E-ISSN
1475-6374
DOI
10.1080/14756366.2021.2017911
