Deep learning enables genetic analysis of the human thoracic aorta
Deep learning enables genetic analysis of the human thoracic aorta
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Author / Creator
Pirruccello, James P. , Chaffin, Mark D. , Chou, Elizabeth L. , Fleming, Stephen J. , Lin, Honghuang , Nekoui, Mahan , Khurshid, Shaan , Friedman, Samuel F. , Bick, Alexander G. , Arduini, Alessandro , Weng, Lu-Chen , Choi, Seung Hoan , Akkad, Amer-Denis , Batra, Puneet , Tucker, Nathan R. , Hall, Amelia W. , Roselli, Carolina , Benjamin, Emelia J. , Vellarikkal, Shamsudheen K. , Gupta, Rajat M. , Stegmann, Christian M. , Juric, Dejan , Stone, James R. , Vasan, Ramachandran S. , Ho, Jennifer E. , Hoffmann, Udo , Lubitz, Steven A. , Philippakis, Anthony A. , Lindsay, Mark E. and Ellinor, Patrick T.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Enlargement or aneurysm of the aorta predisposes to dissection, an important cause of sudden death. We trained a deep learning model to evaluate the dimensions of the ascending and descending thoracic aorta in 4.6 million cardiac magnetic resonance images from the UK Biobank. We then conducted genome-wide association studies in 39,688 individuals,...
Alternative Titles
Full title
Deep learning enables genetic analysis of the human thoracic aorta
Authors, Artists and Contributors
Author / Creator
Chaffin, Mark D.
Chou, Elizabeth L.
Fleming, Stephen J.
Lin, Honghuang
Nekoui, Mahan
Khurshid, Shaan
Friedman, Samuel F.
Bick, Alexander G.
Arduini, Alessandro
Weng, Lu-Chen
Choi, Seung Hoan
Akkad, Amer-Denis
Batra, Puneet
Tucker, Nathan R.
Hall, Amelia W.
Roselli, Carolina
Benjamin, Emelia J.
Vellarikkal, Shamsudheen K.
Gupta, Rajat M.
Stegmann, Christian M.
Juric, Dejan
Stone, James R.
Vasan, Ramachandran S.
Ho, Jennifer E.
Hoffmann, Udo
Lubitz, Steven A.
Philippakis, Anthony A.
Lindsay, Mark E.
Ellinor, Patrick T.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8758523
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8758523
Other Identifiers
ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/s41588-021-00962-4
