Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratificatio...
Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Although the cohort-level accuracy of polygenic risk scores (PRSs)—estimates of genetic value at the individual level—has been widely assessed, uncertainty in PRSs remains underexplored. In the present study, we show that Bayesian PRS methods can estimate the variance of an individual’s PRS and can yield well-calibrated credible intervals via poste...
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Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8758557
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8758557
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ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/s41588-021-00961-5
