Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer
Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer
About this item
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Author / Creator
Xiao, Lanbo , Parolia, Abhijit , Qiao, Yuanyuan , Bawa, Pushpinder , Eyunni, Sanjana , Mannan, Rahul , Carson, Sandra E. , Chang, Yu , Wang, Xiaoju , Zhang, Yuping , Vo, Josh N. , Kregel, Steven , Simko, Stephanie A. , Delekta, Andrew D. , Jaber, Mustapha , Zheng, Heng , Apel, Ingrid J. , McMurry, Lisa , Su, Fengyun , Wang, Rui , Zelenka-Wang, Sylvia , Sasmal, Sanjita , Khare, Leena , Mukherjee, Subhendu , Abbineni, Chandrasekhar , Aithal, Kiran , Bhakta, Mital S. , Ghurye, Jay , Cao, Xuhong , Navone, Nora M. , Nesvizhskii, Alexey I. , Mehra, Rohit , Vaishampayan, Ulka , Blanchette, Marco , Wang, Yuzhuo , Samajdar, Susanta , Ramachandra, Murali and Chinnaiyan, Arul M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin remodelling
1
and is altered in over 20% of cancers
2
,
3
. Here we developed a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4, called AU-15330. Androgen receptor (AR)
+
forkhead box A1 (F...
Alternative Titles
Full title
Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer
Authors, Artists and Contributors
Author / Creator
Parolia, Abhijit
Qiao, Yuanyuan
Bawa, Pushpinder
Eyunni, Sanjana
Mannan, Rahul
Carson, Sandra E.
Chang, Yu
Wang, Xiaoju
Zhang, Yuping
Vo, Josh N.
Kregel, Steven
Simko, Stephanie A.
Delekta, Andrew D.
Jaber, Mustapha
Zheng, Heng
Apel, Ingrid J.
McMurry, Lisa
Su, Fengyun
Wang, Rui
Zelenka-Wang, Sylvia
Sasmal, Sanjita
Khare, Leena
Mukherjee, Subhendu
Abbineni, Chandrasekhar
Aithal, Kiran
Bhakta, Mital S.
Ghurye, Jay
Cao, Xuhong
Navone, Nora M.
Nesvizhskii, Alexey I.
Mehra, Rohit
Vaishampayan, Ulka
Blanchette, Marco
Wang, Yuzhuo
Samajdar, Susanta
Ramachandra, Murali
Chinnaiyan, Arul M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8770127
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8770127
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-04246-z
