Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning...
Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow
About this item
Full title
Author / Creator
Xie, Chenglong , Zhuang, Xu-Xu , Niu, Zhangming , Ai, Ruixue , Lautrup, Sofie , Zheng, Shuangjia , Jiang, Yinghui , Han, Ruiyu , Gupta, Tanima Sen , Cao, Shuqin , Lagartos-Donate, Maria Jose , Cai, Cui-Zan , Xie, Li-Ming , Caponio, Domenica , Wang, Wen-Wen , Schmauck-Medina, Tomas , Zhang, Jianying , Wang, He-ling , Lou, Guofeng , Xiao, Xianglu , Zheng, Wenhua , Palikaras, Konstantinos , Yang, Guang , Caldwell, Kim A. , Caldwell, Guy A. , Shen, Han-Ming , Nilsen, Hilde , Lu, Jia-Hong and Fang, Evandro F.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
A reduced removal of dysfunctional mitochondria is common to aging and age-related neurodegenerative pathologies such as Alzheimer’s disease (AD). Strategies for treating such impaired mitophagy would benefit from the identification of mitophagy modulators. Here we report the combined use of unsupervised machine learning (involving vector represent...
Alternative Titles
Full title
Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow
Authors, Artists and Contributors
Author / Creator
Zhuang, Xu-Xu
Niu, Zhangming
Ai, Ruixue
Lautrup, Sofie
Zheng, Shuangjia
Jiang, Yinghui
Han, Ruiyu
Gupta, Tanima Sen
Cao, Shuqin
Lagartos-Donate, Maria Jose
Cai, Cui-Zan
Xie, Li-Ming
Caponio, Domenica
Wang, Wen-Wen
Schmauck-Medina, Tomas
Zhang, Jianying
Wang, He-ling
Lou, Guofeng
Xiao, Xianglu
Zheng, Wenhua
Palikaras, Konstantinos
Yang, Guang
Caldwell, Kim A.
Caldwell, Guy A.
Shen, Han-Ming
Nilsen, Hilde
Lu, Jia-Hong
Fang, Evandro F.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8782726
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8782726
Other Identifiers
ISSN
2157-846X
E-ISSN
2157-846X
DOI
10.1038/s41551-021-00819-5
