Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug
Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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We report two structures of the human voltage-gated potassium channel (Kv) Kv1.3 in immune cells alone (apo-Kv1.3) and bound to an immunomodulatory drug called dalazatide (dalazatide–Kv1.3). Both the apo-Kv1.3 and dalazatide–Kv1.3 structures are in an activated state based on their depolarized voltage sensor and open inner gate. In apo-Kv1.3, the a...
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Full title
Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8812516
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8812516
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2113536119
