TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization
TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization
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Author / Creator
Gao, Wenqing , Li, Yuanyuan , Liu, Xuehe , Wang, Sen , Mei, Pucheng , Chen, Zijun , Liu, Kewei , Li, Suhua , Xu, Xue-Wei , Gan, Jianhua , Wu, Jiaxue , Ji, Chaoneng , Ding, Chen , Liu, Xing , Lai, Yuping , He, Housheng Hansen , Lieberman, Judy , Wu, Hao , Chen, Xiangjun and Li, Jixi
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Gasdermin-D (GSDMD), the executioner of pyroptotic cell death when it is cleaved by inflammatory caspases, plays a crucial role in host defense and the response to danger signals. So far, there are no known mechanisms, other than cleavage, for regulating GSDMD. Here, we show that tripartite motif protein TRIM21 acts as a positive regulator of GSDMD...
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Full title
TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8817046
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8817046
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-021-00867-z
