Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-...
Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level
About this item
Full title
Author / Creator
Johnson, Erik C. B. , Carter, E. Kathleen , Dammer, Eric B. , Duong, Duc M. , Gerasimov, Ekaterina S. , Liu, Yue , Liu, Jiaqi , Betarbet, Ranjita , Ping, Lingyan , Yin, Luming , Serrano, Geidy E. , Beach, Thomas G. , Peng, Junmin , De Jager, Philip L. , Haroutunian, Vahram , Zhang, Bin , Gaiteri, Chris , Bennett, David A. , Gearing, Marla , Wingo, Thomas S. , Wingo, Aliza P. , Lah, James J. , Levey, Allan I. and Seyfried, Nicholas T.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The biological processes that are disrupted in the Alzheimer’s disease (AD) brain remain incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain tissues to reveal new AD-related protein co-expression modules that were highly preserved across cohorts and brain regions. Nearly half of the protein co-expression modul...
Alternative Titles
Full title
Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level
Authors, Artists and Contributors
Author / Creator
Carter, E. Kathleen
Dammer, Eric B.
Duong, Duc M.
Gerasimov, Ekaterina S.
Liu, Yue
Liu, Jiaqi
Betarbet, Ranjita
Ping, Lingyan
Yin, Luming
Serrano, Geidy E.
Beach, Thomas G.
Peng, Junmin
De Jager, Philip L.
Haroutunian, Vahram
Zhang, Bin
Gaiteri, Chris
Bennett, David A.
Gearing, Marla
Wingo, Thomas S.
Wingo, Aliza P.
Lah, James J.
Levey, Allan I.
Seyfried, Nicholas T.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8825285
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8825285
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-021-00999-y
