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Asymmetric activation of the calcium-sensing receptor homodimer

Asymmetric activation of the calcium-sensing receptor homodimer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8826748

Asymmetric activation of the calcium-sensing receptor homodimer

About this item

Full title

Asymmetric activation of the calcium-sensing receptor homodimer

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2021-07, Vol.595 (7867), p.455-459

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The calcium-sensing receptor (CaSR), a cell-surface sensor for Ca
2+
, is the master regulator of calcium homeostasis in humans and is the target of calcimimetic drugs for the treatment of parathyroid disorders
1
. CaSR is a family C G-protein-coupled receptor
2
that functions as an obligate homodimer, with each protomer composed...

Alternative Titles

Full title

Asymmetric activation of the calcium-sensing receptor homodimer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8826748

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8826748

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-021-03691-0

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