dCas9-based gene editing for cleavage-free genomic knock-in of long sequences
dCas9-based gene editing for cleavage-free genomic knock-in of long sequences
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Gene editing is a powerful tool for genome and cell engineering. Exemplified by CRISPR–Cas, gene editing could cause DNA damage and trigger DNA repair processes that are often error-prone. Such unwanted mutations and safety concerns can be exacerbated when altering long sequences. Here we couple microbial single-strand annealing proteins (SSAPs) wi...
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Full title
dCas9-based gene editing for cleavage-free genomic knock-in of long sequences
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8843813
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8843813
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-021-00836-1
