Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
About this item
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Author / Creator
Chu, Ting-Ting , Tu, Xintao , Yang, Kun , Wu, Jianjun , Repa, Joyce J. and Yan, Nan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The classic mode of STING activation is through binding the cyclic dinucleotide 2′3′-cyclic GMP–AMP (cGAMP), produced by the DNA sensor cyclic GMP–AMP synthase (cGAS), which is important for the innate immune response to microbial infection and autoimmune disease. Modes of STING activation that are independent of cGAS are much less well understood....
Alternative Titles
Full title
Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8859990
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8859990
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-021-03762-2
