Structures of the σ2 receptor enable docking for bioactive ligand discovery
Structures of the σ2 receptor enable docking for bioactive ligand discovery
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The σ
2
receptor has attracted intense interest in cancer imaging
1
, psychiatric disease
2
, neuropathic pain
3
–
5
and other areas of biology
6
,
7
. Here we determined the crystal structure of this receptor in complex with the clinical candidate roluperidone
2
and the tool compound PB28
8
. T...
Alternative Titles
Full title
Structures of the σ2 receptor enable docking for bioactive ligand discovery
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8867396
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8867396
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-021-04175-x
