Multiple genetic paths including massive gene amplification allow Mycobacterium tuberculosis to over...
Multiple genetic paths including massive gene amplification allow Mycobacterium tuberculosis to overcome loss of ESX-3 secretion system substrates
About this item
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Author / Creator
Wang, Lin , Asare, Emmanuel , Shetty, Amol C. , Sanchez-Tumbaco, Freddy , Edwards, Megan R. , Saranathan, Rajagopalan , Weinrick, Brian , Xu, Jiayong , Chen, Bing , Bénard, Angèle , Dougan, Gordon , Leung, Daisy W. , Amarasinghe, Gaya K. , Chan, John , Basler, Christopher F. , Jacobs, William R. and Tufariello, JoAnn M.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Mycobacterium tuberculosis (Mtb) possesses five type VII secretion systems (T7SS), virulence determinants that include the secretion apparatus and associated secretion substrates. Mtb strains deleted for the genes encoding substrates of the ESX-3 T7SS, esxG or esxH, require iron supplementation for in vitro growth and are highly attenuated in vivo....
Alternative Titles
Full title
Multiple genetic paths including massive gene amplification allow Mycobacterium tuberculosis to overcome loss of ESX-3 secretion system substrates
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8872769
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8872769
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2112608119
