Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism
Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism
About this item
Full title
Author / Creator
Urresti, Jorge , Zhang, Pan , Moran-Losada, Patricia , Yu, Nam-Kyung , Negraes, Priscilla D. , Trujillo, Cleber A. , Antaki, Danny , Amar, Megha , Chau, Kevin , Pramod, Akula Bala , Diedrich, Jolene , Tejwani, Leon , Romero, Sarah , Sebat, Jonathan , Yates III, John R. , Muotri, Alysson R. and Iakoucheva, Lilia M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Reciprocal deletion and duplication of the 16p11.2 region is the most common copy number variation (CNV) associated with autism spectrum disorders. We generated cortical organoids from skin fibroblasts of patients with 16p11.2 CNV to investigate impacted neurodevelopmental processes. We show that organoid size recapitulates macrocephaly and microce...
Alternative Titles
Full title
Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8873019
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8873019
Other Identifiers
ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/s41380-021-01243-6
