CRL4AMBRA1 is a master regulator of D-type cyclins
CRL4AMBRA1 is a master regulator of D-type cyclins
About this item
Full title
Author / Creator
Simoneschi, Daniele , Rona, Gergely , Zhou, Nan , Jeong, Yeon-Tae , Jiang, Shaowen , Milletti, Giacomo , Arbini, Arnaldo A. , O’Sullivan, Alfie , Wang, Andrew A. , Nithikasem, Sorasicha , Keegan, Sarah , Siu, Yik , Cianfanelli, Valentina , Maiani, Emiliano , Nazio, Francesca , Cecconi, Francesco , Boccalatte, Francesco , Fenyö, David , Jones, Drew R. , Busino, Luca and Pagano, Michele
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
D-type cyclins are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer
1
, but the mechanisms that regulate their turnover are still being debated
2
,
3
. Here, by combining biochemical and genetics studies in somatic cells, we identify CRL4
AMBRA1
(...
Alternative Titles
Full title
CRL4AMBRA1 is a master regulator of D-type cyclins
Authors, Artists and Contributors
Author / Creator
Rona, Gergely
Zhou, Nan
Jeong, Yeon-Tae
Jiang, Shaowen
Milletti, Giacomo
Arbini, Arnaldo A.
O’Sullivan, Alfie
Wang, Andrew A.
Nithikasem, Sorasicha
Keegan, Sarah
Siu, Yik
Cianfanelli, Valentina
Maiani, Emiliano
Nazio, Francesca
Cecconi, Francesco
Boccalatte, Francesco
Fenyö, David
Jones, Drew R.
Busino, Luca
Pagano, Michele
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8875297
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8875297
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-03445-y
