ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP product...
ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation
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Publisher
Cham: Springer International Publishing
Journal title
Language
English
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Publisher
Cham: Springer International Publishing
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Contents
Cellular senescence is closely related to tissue aging including bone. Bone homeostasis is maintained by the tight balance between bone-forming osteoblasts and bone-resorbing osteoclasts, but it undergoes deregulation with age, causing age-associated osteoporosis, a main cause of which is osteoblast dysfunction. Oxidative stress caused by the accum...
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Full title
ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8882118
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8882118
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ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-022-04186-5
