Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and...
Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function
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Author / Creator
Basu, Jayati , Reis, Bernardo S. , Peri, Suraj , Zha, Jikun , Hua, Xiang , Ge, Lu , Ferchen, Kyle , Nicolas, Emmanuelle , Czyzewicz, Philip , Cai, Kathy Q. , Tan, Yinfei , Fuxman Bass, Juan I. , Walhout, Albertha J. M. , Grimes, H. Leighton , Grivennikov, Sergei I. , Mucida, Daniel and Kappes, Dietmar J.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The transcription factor ThPOK (encoded by the
Zbtb7b
gene) controls homeostasis and differentiation of mature helper T cells, while opposing their differentiation to CD4
+
intraepithelial lymphocytes (IELs) in the intestinal mucosa. Thus CD4 IEL differentiation requires
ThPOK
transcriptional repression via reactivation of the
...
Alternative Titles
Full title
Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8887595
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8887595
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-021-00980-8
