Antitumor Necrosis Factor-like Ligand 1A Therapy Targets Tissue Inflammation and Fibrosis Pathways a...
Antitumor Necrosis Factor-like Ligand 1A Therapy Targets Tissue Inflammation and Fibrosis Pathways and Reduces Gut Pathobionts in Ulcerative Colitis
About this item
Full title
Author / Creator
Hassan-Zahraee, Mina , Ye, Zhan , Xi, Li , Baniecki, Mary Lynn , Li, Xingpeng , Hyde, Craig L , Zhang, Jenny , Raha, Nancy , Karlsson, Fridrik , Quan, Jie , Ziemek, Daniel , Neelakantan, Srividya , Lepsy, Christopher , Allegretti, Jessica R , Romatowski, Jacek , Scherl, Ellen J , Klopocka, Maria , Danese, Silvio , Chandra, Deepa E , Schoenbeck, Uwe , Vincent, Michael S , Longman, Randy and Hung, Kenneth E
Publisher
US: Oxford University Press
Journal title
Language
English
Formats
Publication information
Publisher
US: Oxford University Press
Subjects
More information
Scope and Contents
Contents
Abstract
Background
The first-in-class treatment PF-06480605 targets the tumor necrosis factor-like ligand 1A (TL1A) molecule in humans. Results from the phase 2a TUSCANY trial highlighted the safety and efficacy of PF-06480605 in ulcerative colitis. Preclinical and in vitro models have identified a role for TL1A in both innate and adaptive i...
Alternative Titles
Full title
Antitumor Necrosis Factor-like Ligand 1A Therapy Targets Tissue Inflammation and Fibrosis Pathways and Reduces Gut Pathobionts in Ulcerative Colitis
Authors, Artists and Contributors
Author / Creator
Ye, Zhan
Xi, Li
Baniecki, Mary Lynn
Li, Xingpeng
Hyde, Craig L
Zhang, Jenny
Raha, Nancy
Karlsson, Fridrik
Quan, Jie
Ziemek, Daniel
Neelakantan, Srividya
Lepsy, Christopher
Allegretti, Jessica R
Romatowski, Jacek
Scherl, Ellen J
Klopocka, Maria
Danese, Silvio
Chandra, Deepa E
Schoenbeck, Uwe
Vincent, Michael S
Longman, Randy
Hung, Kenneth E
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8889296
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8889296
Other Identifiers
ISSN
1078-0998
E-ISSN
1536-4844
DOI
10.1093/ibd/izab193
