TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
About this item
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Author / Creator
Ma, X. Rosa , Prudencio, Mercedes , Koike, Yuka , Vatsavayai, Sarat C. , Kim, Garam , Harbinski, Fred , Briner, Adam , Rodriguez, Caitlin M. , Guo, Caiwei , Akiyama, Tetsuya , Schmidt, H. Broder , Cummings, Beryl B. , Wyatt, David W. , Kurylo, Katherine , Miller, Georgiana , Mekhoubad, Shila , Sallee, Nathan , Mekonnen, Gemechu , Ganser, Laura , Rubien, Jack D. , Jansen-West, Karen , Cook, Casey N. , Pickles, Sarah , Oskarsson, Björn , Graff-Radford, Neill R. , Boeve, Bradley F. , Knopman, David S. , Petersen, Ronald C. , Dickson, Dennis W. , Shorter, James , Myong, Sua , Green, Eric M. , Seeley, William W. , Petrucelli, Leonard and Gitler, Aaron D.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-43 from the nucleus of neurons in the brain and spinal cord
1
. A major function of TDP-43 is as a repressor of cryptic exon inclusion during RNA splicing
2
–...
Alternative Titles
Full title
TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
Authors, Artists and Contributors
Author / Creator
Prudencio, Mercedes
Koike, Yuka
Vatsavayai, Sarat C.
Kim, Garam
Harbinski, Fred
Briner, Adam
Rodriguez, Caitlin M.
Guo, Caiwei
Akiyama, Tetsuya
Schmidt, H. Broder
Cummings, Beryl B.
Wyatt, David W.
Kurylo, Katherine
Miller, Georgiana
Mekhoubad, Shila
Sallee, Nathan
Mekonnen, Gemechu
Ganser, Laura
Rubien, Jack D.
Jansen-West, Karen
Cook, Casey N.
Pickles, Sarah
Oskarsson, Björn
Graff-Radford, Neill R.
Boeve, Bradley F.
Knopman, David S.
Petersen, Ronald C.
Dickson, Dennis W.
Shorter, James
Myong, Sua
Green, Eric M.
Seeley, William W.
Petrucelli, Leonard
Gitler, Aaron D.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8891019
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8891019
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04424-7
