DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Ferroptosis, a form of regulated cell death that is induced by excessive lipid peroxidation, is a key tumour suppression mechanism
1
–
4
. Glutathione peroxidase 4 (GPX4)
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,
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and ferroptosis suppressor protein 1 (FSP1)
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,
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constitute two major ferroptosis defence systems. Here we show that treatment of cancer...
Alternative Titles
Full title
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8895686
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8895686
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-03539-7
