ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth
About this item
Full title
Author / Creator
Remsberg, Jarrett R. , Suciu, Radu M. , Zambetti, Noemi A. , Hanigan, Thomas W. , Firestone, Ari J. , Inguva, Anagha , Long, Amanda , Ngo, Nhi , Lum, Kenneth M. , Henry, Cassandra L. , Richardson, Stewart K. , Predovic, Marina , Huang, Ben , Dix, Melissa M. , Howell, Amy R. , Niphakis, Micah J. , Shannon, Kevin and Cravatt, Benjamin F.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as Palmostatin M (Palm M) block N-Ras depalmitoylation, but lack specificity and target several enzymes displaying depalmitoylase activity. Here, we describe ABD957, a p...
Alternative Titles
Full title
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth
Authors, Artists and Contributors
Author / Creator
Suciu, Radu M.
Zambetti, Noemi A.
Hanigan, Thomas W.
Firestone, Ari J.
Inguva, Anagha
Long, Amanda
Ngo, Nhi
Lum, Kenneth M.
Henry, Cassandra L.
Richardson, Stewart K.
Predovic, Marina
Huang, Ben
Dix, Melissa M.
Howell, Amy R.
Niphakis, Micah J.
Shannon, Kevin
Cravatt, Benjamin F.
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8900659
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8900659
Other Identifiers
ISSN
1552-4450,1552-4469
E-ISSN
1552-4469
DOI
10.1038/s41589-021-00785-8
