Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leuke...
Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax
About this item
Full title
Author / Creator
Fidyt, Klaudyna , Pastorczak, Agata , Cyran, Julia , Crump, Nicholas T. , Goral, Agnieszka , Madzio, Joanna , Muchowicz, Angelika , Poprzeczko, Martyna , Domka, Krzysztof , Komorowski, Lukasz , Winiarska, Magdalena , Harman, Joe R. , Siudakowska, Karolina , Graczyk-Jarzynka, Agnieszka , Patkowska, Elzbieta , Lech-Maranda, Ewa , Mlynarski, Wojciech , Golab, Jakub , Milne, Thomas A. and Firczuk, Malgorzata
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The prognosis for B-cell precursor acute lymphoblastic leukemia patients with
Mixed-Lineage Leukemia
(
MLL
) gene rearrangements (MLLr BCP-ALL) is still extremely poor. Inhibition of anti-apoptotic protein BCL-2 with venetoclax emerged as a promising strategy for this subtype of BCP-ALL, however, lack of sufficient responses in preclini...
Alternative Titles
Full title
Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax
Authors, Artists and Contributors
Author / Creator
Pastorczak, Agata
Cyran, Julia
Crump, Nicholas T.
Goral, Agnieszka
Madzio, Joanna
Muchowicz, Angelika
Poprzeczko, Martyna
Domka, Krzysztof
Komorowski, Lukasz
Winiarska, Magdalena
Harman, Joe R.
Siudakowska, Karolina
Graczyk-Jarzynka, Agnieszka
Patkowska, Elzbieta
Lech-Maranda, Ewa
Mlynarski, Wojciech
Golab, Jakub
Milne, Thomas A.
Firczuk, Malgorzata
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8913358
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8913358
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-022-02196-y
