Repeat expansions confer WRN dependence in microsatellite-unstable cancers
Repeat expansions confer WRN dependence in microsatellite-unstable cancers
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Author / Creator
van Wietmarschen, Niek , Sridharan, Sriram , Nathan, William J. , Tubbs, Anthony , Chan, Edmond M. , Callen, Elsa , Wu, Wei , Belinky, Frida , Tripathi, Veenu , Wong, Nancy , Foster, Kyla , Noorbakhsh, Javad , Garimella, Kiran , Cruz-Migoni, Abimael , Sommers, Joshua A. , Huang, Yongqing , Borah, Ashir A. , Smith, Jonathan T. , Kalfon, Jeremie , Kesten, Nikolas , Fugger, Kasper , Walker, Robert L. , Dolzhenko, Egor , Eberle, Michael A. , Hayward, Bruce E. , Usdin, Karen , Freudenreich, Catherine H. , Brosh, Robert M. , West, Stephen C. , McHugh, Peter J. , Meltzer, Paul S. , Bass, Adam J. and Nussenzweig, André
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with microsatellite instability (MSI), a form of genetic hypermutability that arises from impaired mismatch repair
1
–
4
. Depletion of WRN induces widespread DNA double-strand breaks in MSI cells, leading to cell cycle arrest and/or apoptosis. However, the mechanis...
Alternative Titles
Full title
Repeat expansions confer WRN dependence in microsatellite-unstable cancers
Authors, Artists and Contributors
Author / Creator
Sridharan, Sriram
Nathan, William J.
Tubbs, Anthony
Chan, Edmond M.
Callen, Elsa
Wu, Wei
Belinky, Frida
Tripathi, Veenu
Wong, Nancy
Foster, Kyla
Noorbakhsh, Javad
Garimella, Kiran
Cruz-Migoni, Abimael
Sommers, Joshua A.
Huang, Yongqing
Borah, Ashir A.
Smith, Jonathan T.
Kalfon, Jeremie
Kesten, Nikolas
Fugger, Kasper
Walker, Robert L.
Dolzhenko, Egor
Eberle, Michael A.
Hayward, Bruce E.
Usdin, Karen
Freudenreich, Catherine H.
Brosh, Robert M.
West, Stephen C.
McHugh, Peter J.
Meltzer, Paul S.
Bass, Adam J.
Nussenzweig, André
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8916167
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8916167
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2769-8
