Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis
Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-related protein misfolding diseases
1
,
2
. Yet, how ageing impairs proteostasis remains unclear. As nascent polypeptides represent a substantial burden on the proteostasis network
3
, we hypothesized that altered translational efficiency during...
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Full title
Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8918044
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8918044
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-04295-4
