Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in...
Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in retinitis pigmentosa
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Methods to stimulate protein degradation through the ubiquitin-proteasome system (UPS) are being investigated as approaches to treat multiple human diseases and delay aging. Recent studies highlighted a nontrivial relationship between the mammalian target of rapamycin complex 1 (mTORC1) pathway and the UPS. In different experimental models, both ac...
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Full title
Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in retinitis pigmentosa
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8931319
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8931319
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ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.2118479119
