Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer...
Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth
About this item
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Author / Creator
Jin, Ying , Pan, Yamu , Zheng, Shuang , Liu, Yao , Xu, Jie , Peng, Yazhi , Zhang, Zemei , Wang, Yadong , Xiong, Yulian , Xu, Lei , Mu, Kaiyu , Chen, Suwen , Zheng, Fei , Yuan, Ye and Fu, Jian
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
EGLN3 is critically important for growth of various cancers including lung cancer. However, virtually nothing is known about the role and mechanism for EGLN3 hydroxylase activity in cancers. EGLN3 catalyzes the hydroxylation of extracellular signal-regulated kinase 3 (Erk3), a potent driver of cancers. The role and mechanism for EGLN3-induced stabi...
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Full title
Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8933280
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8933280
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-022-02203-2
