Rational engineering of a functional CpG-free ITR for AAV gene therapy
Rational engineering of a functional CpG-free ITR for AAV gene therapy
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Inverted terminal repeats (ITRs) are the only wild-type components retained in the genome of adeno-associated virus (AAV) vectors. To determine whether ITR modification is a viable approach for AAV vector engineering, we rationally deleted all CpG motifs in the ITR and examined whether CpG elimination compromises AAV-vector production and transduct...
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Full title
Rational engineering of a functional CpG-free ITR for AAV gene therapy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8983793
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8983793
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ISSN
0969-7128
E-ISSN
1476-5462
DOI
10.1038/s41434-021-00296-0
