A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4+...
A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4+ T cells and is defective in Crohn´s disease patients
About this item
Full title
Author / Creator
Ahlers, Jonas , Mantei, Andrej , Lozza, Laura , Stäber, Manuela , Heinrich, Frederik , Bacher, Petra , Hohnstein, Thordis , Menzel, Lutz , Yüz, Simge G. , Alvarez-Simon, Daniel , Bickenbach, Anne Rieke , Weidinger, Carl , Mockel-Tenbrinck, Nadine , Kühl, Anja A. , Siegmund, Britta , Maul, Jochen , Neumann, Christian and Scheffold, Alexander
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Immunosuppressive Interleukin (IL)−10 production by pro-inflammatory CD4
+
T cells is a central self-regulatory function to limit aberrant inflammation. Still, the molecular mediators controlling IL-10 expression in human CD4
+
T cells are largely undefined. Here, we identify a Notch/STAT3 signaling-module as a universal molecular switc...
Alternative Titles
Full title
A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4+ T cells and is defective in Crohn´s disease patients
Authors, Artists and Contributors
Author / Creator
Mantei, Andrej
Lozza, Laura
Stäber, Manuela
Heinrich, Frederik
Bacher, Petra
Hohnstein, Thordis
Menzel, Lutz
Yüz, Simge G.
Alvarez-Simon, Daniel
Bickenbach, Anne Rieke
Weidinger, Carl
Mockel-Tenbrinck, Nadine
Kühl, Anja A.
Siegmund, Britta
Maul, Jochen
Neumann, Christian
Scheffold, Alexander
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9038525
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9038525
Other Identifiers
ISSN
1933-0219
E-ISSN
1935-3456
DOI
10.1038/s41385-022-00487-x
