An effective AKT inhibitor-PARP inhibitor combination therapy for recurrent ovarian cancer
An effective AKT inhibitor-PARP inhibitor combination therapy for recurrent ovarian cancer
About this item
Full title
Author / Creator
Xu, Jing , Gao, Yi , Luan, Xiaotian , Li, Ke , Wang, Jing , Dai, Yilin , Kang, Mingyi , Lu, Chong , Zhang, Minhua , Lu, Chris X. , Kang, Yu and Xu, Congjian
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Background
Although the use of PARP inhibitor has received considerable amount of attention in ovarian cancer, PARP inhibitor resistance still emerges with disease progression. PI3K/AKT pathway inhibitors have been proposed to synergize with PARP inhibition to slow tumor growth, but the exact molecular mechanisms are still elusive.
Methods
Alternative Titles
Full title
An effective AKT inhibitor-PARP inhibitor combination therapy for recurrent ovarian cancer
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9054880
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9054880
Other Identifiers
ISSN
0344-5704
E-ISSN
1432-0843
DOI
10.1007/s00280-022-04403-9
