Enzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead
Enzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The marine microbial natural product salinosporamide A (marizomib) is a potent proteasome inhibitor currently in clinical trials for the treatment of brain cancer. Salinosporamide A is characterized by a complex and densely functionalized γ-lactam-β-lactone bicyclic warhead, the assembly of which has long remained a biosynthetic mystery. Here, we r...
Alternative Titles
Full title
Enzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9058210
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9058210
Other Identifiers
ISSN
1552-4450,1552-4469
E-ISSN
1552-4469
DOI
10.1038/s41589-022-00993-w
