Neurofibromin and suppression of tumorigenesis: beyond the GAP
Neurofibromin and suppression of tumorigenesis: beyond the GAP
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Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease and one of the most common inherited tumor predisposition syndromes, affecting 1 in 3000 individuals worldwide. The
NF1
gene encodes neurofibromin, a large protein with RAS GTP-ase activating (RAS-GAP) activity, and loss of
NF1
results in increased RAS signaling. Ne...
Alternative Titles
Full title
Neurofibromin and suppression of tumorigenesis: beyond the GAP
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9063229
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9063229
Other Identifiers
ISSN
0950-9232,1476-5594
E-ISSN
1476-5594
DOI
10.1038/s41388-021-02156-y
