Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel s...
Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome
About this item
Full title
Author / Creator
Edwinson, Adam L. , Yang, Lu , Peters, Stephanie , Hanning, Nikita , Jeraldo, Patricio , Jagtap, Pratik , Simpson, Joshua B. , Yang, Tzu-Yi , Kumar, Praveen , Mehta, Subina , Nair, Asha , Breen-Lyles, Margaret , Chikkamenahalli, Lakshmikanth , Graham, Rondell P. , De Winter, Benedicte , Patel, Robin , Dasari, Surendra , Kashyap, Purna , Griffin, Timothy , Chen, Jun , Farrugia, Gianrico , Redinbo, Matthew R. and Grover, Madhusudan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Intestinal proteases mediate digestion and immune signalling, while increased gut proteolytic activity disrupts the intestinal barrier and generates visceral hypersensitivity, which is common in irritable bowel syndrome (IBS). However, the mechanisms controlling protease function are unclear. Here we show that members of the gut microbiota suppress...
Alternative Titles
Full title
Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome
Authors, Artists and Contributors
Author / Creator
Yang, Lu
Peters, Stephanie
Hanning, Nikita
Jeraldo, Patricio
Jagtap, Pratik
Simpson, Joshua B.
Yang, Tzu-Yi
Kumar, Praveen
Mehta, Subina
Nair, Asha
Breen-Lyles, Margaret
Chikkamenahalli, Lakshmikanth
Graham, Rondell P.
De Winter, Benedicte
Patel, Robin
Dasari, Surendra
Kashyap, Purna
Griffin, Timothy
Chen, Jun
Farrugia, Gianrico
Redinbo, Matthew R.
Grover, Madhusudan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9081267
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9081267
Other Identifiers
ISSN
2058-5276
E-ISSN
2058-5276
DOI
10.1038/s41564-022-01103-1
