The genotypes and phenotypes of missense mutations in the proline domain of the p53 protein
The genotypes and phenotypes of missense mutations in the proline domain of the p53 protein
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The p53 protein is structurally and functionally divided into five domains. The proline-rich domain is localized at amino acids 55–100. 319 missense mutations were identified solely in the proline domain from human cancers. Six hotspot mutations were identified at amino acids 72, 73, 82, 84, 89, and 98. Codon 72 contains a polymorphism that changes...
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Full title
The genotypes and phenotypes of missense mutations in the proline domain of the p53 protein
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9090814
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9090814
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-022-00980-7
