Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus–infected rhesus macaques...
Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus–infected rhesus macaques on antiretroviral therapy
About this item
Full title
Author / Creator
Varco-Merth, Benjamin D. , Brantley, William , Marenco, Alejandra , Duell, Derick D. , Fachko, Devin N. , Richardson, Brian , Busman-Sahay, Kathleen , Shao, Danica , Flores, Walter , Engelman, Kathleen , Fukazawa, Yoshinori , Wong, Scott W. , Skalsky, Rebecca L. , Smedley, Jeremy , Axthelm, Michael K. , Lifson, Jeffrey D. , Estes, Jacob D. , Edlefsen, Paul T. , Picker, Louis J. , Cameron, Cheryl M.A. , Henrich, Timothy J. and Okoye, Afam A.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Proliferation of latently infected CD4+ T cells with replication-competent proviruses is an important mechanism contributing to HIV persistence during antiretroviral therapy (ART). One approach to targeting this latent cell expansion is to inhibit mTOR, a regulatory kinase involved with cell growth, metabolism, and proliferation. Here, we determine...
Alternative Titles
Full title
Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus–infected rhesus macaques on antiretroviral therapy
Authors, Artists and Contributors
Author / Creator
Brantley, William
Marenco, Alejandra
Duell, Derick D.
Fachko, Devin N.
Richardson, Brian
Busman-Sahay, Kathleen
Shao, Danica
Flores, Walter
Engelman, Kathleen
Fukazawa, Yoshinori
Wong, Scott W.
Skalsky, Rebecca L.
Smedley, Jeremy
Axthelm, Michael K.
Lifson, Jeffrey D.
Estes, Jacob D.
Edlefsen, Paul T.
Picker, Louis J.
Cameron, Cheryl M.A.
Henrich, Timothy J.
Okoye, Afam A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9106346
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9106346
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI156063
