Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible fo...
Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
WNT signalling has multiple roles. It maintains pluripotency of embryonic stem cells, assigns posterior identity in the epiblast and induces mesodermal tissue. Here we provide evidence that these distinct functions are conducted by the transcription factor SOX2, which adopts different modes of chromatin interaction and regulatory element selection...
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Full title
Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9106585
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9106585
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ISSN
1465-7392,1476-4679
E-ISSN
1476-4679
DOI
10.1038/s41556-022-00910-2
