The schizophrenia-associated variant in SLC39A8 alters protein glycosylation in the mouse brain
The schizophrenia-associated variant in SLC39A8 alters protein glycosylation in the mouse brain
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
A missense mutation (A391T) in
SLC39A8
is strongly associated with schizophrenia in genomic studies, though the molecular connection to the brain is unknown. Human carriers of A391T have reduced serum manganese, altered plasma glycosylation, and brain MRI changes consistent with altered metal transport. Here, using a knock-in mouse model homo...
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Full title
The schizophrenia-associated variant in SLC39A8 alters protein glycosylation in the mouse brain
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9106890
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9106890
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ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/s41380-022-01490-1
