Sotorasib for Lung Cancers with KRAS p.G12C Mutation
Sotorasib for Lung Cancers with KRAS p.G12C Mutation
About this item
Full title
Author / Creator
Skoulidis, Ferdinandos , Li, Bob T , Dy, Grace K , Price, Timothy J , Falchook, Gerald S , Wolf, Jürgen , Italiano, Antoine , Schuler, Martin , Borghaei, Hossein , Barlesi, Fabrice , Kato, Terufumi , Curioni-Fontecedro, Alessandra , Sacher, Adrian , Spira, Alexander , Ramalingam, Suresh S , Takahashi, Toshiaki , Besse, Benjamin , Anderson, Abraham , Ang, Agnes , Tran, Qui , Mather, Omar , Henary, Haby , Ngarmchamnanrith, Gataree , Friberg, Gregory , Velcheti, Vamsidhar and Govindan, Ramaswamy
Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
Formats
Publication information
Publisher
United States: Massachusetts Medical Society
Subjects
More information
Scope and Contents
Contents
Sotorasib is a selective irreversible inhibitor of the G12C-activated
KRAS
oncogene, present in approximately 13% of non–small-cell lung cancers. In a single-group, phase 2 trial involving 126 patients with previously treated
KRAS
p.G12C–mutated NSCLC, 37% had a response (median duration, 11 months). One fifth of patients had grade 3 to...
Alternative Titles
Full title
Sotorasib for Lung Cancers with KRAS p.G12C Mutation
Authors, Artists and Contributors
Author / Creator
Li, Bob T
Dy, Grace K
Price, Timothy J
Falchook, Gerald S
Wolf, Jürgen
Italiano, Antoine
Schuler, Martin
Borghaei, Hossein
Barlesi, Fabrice
Kato, Terufumi
Curioni-Fontecedro, Alessandra
Sacher, Adrian
Spira, Alexander
Ramalingam, Suresh S
Takahashi, Toshiaki
Besse, Benjamin
Anderson, Abraham
Ang, Agnes
Tran, Qui
Mather, Omar
Henary, Haby
Ngarmchamnanrith, Gataree
Friberg, Gregory
Velcheti, Vamsidhar
Govindan, Ramaswamy
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9116274
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9116274
Other Identifiers
ISSN
0028-4793,1533-4406
E-ISSN
1533-4406
DOI
10.1056/NEJMoa2103695
