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Structure, function and pharmacology of human itch GPCRs

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Structure, function and pharmacology of human itch GPCRs

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9150435

Structure, function and pharmacology of human itch GPCRs

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Publisher

London: Nature Publishing Group UK

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Contents

The MRGPRX family of receptors (MRGPRX1–4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently
1
. Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-mediated hypersensitivity reactions
2
–
5
. MRGPRX2 couples to both G
i
and G...

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Full title

Structure, function and pharmacology of human itch GPCRs

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9150435

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9150435

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ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-021-04126-6

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