CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobact...
CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis
About this item
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Author / Creator
Li, Shuqi , Poulton, Nicholas C. , Chang, Jesseon S. , Azadian, Zachary A. , DeJesus, Michael A. , Ruecker, Nadine , Zimmerman, Matthew D. , Eckartt, Kathryn A. , Bosch, Barbara , Engelhart, Curtis A. , Sullivan, Daniel F. , Gengenbacher, Martin , Dartois, Véronique A. , Schnappinger, Dirk and Rock, Jeremy M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Mycobacterium tuberculosis
(Mtb) infection is notoriously difficult to treat. Treatment efficacy is limited by Mtb’s intrinsic drug resistance, as well as its ability to evolve acquired resistance to all antituberculars in clinical use. A deeper understanding of the bacterial pathways that influence drug efficacy could facilitate the development...
Alternative Titles
Full title
CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9159947
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9159947
Other Identifiers
ISSN
2058-5276
E-ISSN
2058-5276
DOI
10.1038/s41564-022-01130-y
